top of page
advs202470240-gra-0001-m.jpg

Breast Cancer Stem Cells

Article number 2404853 by Kai Zhang, Qi Mei, Rong Sun, Haiquan Lu, and co-workers reveals the critical role of polyamine anabolism in chemotherapy-induced breast cancer stem cell (BCSC) enrichment. Chemotherapy induces the transcription factor HIF-1-regulated ODC1 and SRM expression and activates polyamine anabolism, which finally leads to enrichment of BCSCs. This study provides a novel strategy for breast cancer treatment by identifying a novel specific HIF-1 inhibitor, britannin, which effectively blocks chemotherapy-induced polyamine anabolism and BCSC enrichment.

Environment and Social Responsibility

Discuss environmental conservation, sustainable living, and volunteer activities that teens can join.

Our Mission

We are committed to inspire and guide young minds by fostering a sense of responsibility, creativity, and resilience, equipping them with the tools to lead with purpose and integrity. Future Leader magazine is dedicated to cultivating positive energy, progressive thinking, and impactful change in youth across diverse fields.

GAMES

19.jpg

Metaphor ReFantazio

Atlus has been firing on all cylinders over the last couple of years with its Persona games, but Metaphor ReFantazio is arguably the studio at its very best.

51.png

Elden Ring

GameSpot's first game to earn a rare 10/10 score, in 2024 Shadow of the Erdtree is everything you love about Elden Ring and delivered with perfect execution. 

微信截图_20241103235608.png

Dragon's Dogma

12 years after the first game came out, Dragon's Dogma 2 builds on the best parts of that sweeping fantasy tale to deliver a magical open-world RPG. 

DEC 2024.png

Subscribe to our newsletter • Don’t miss out!

Birthday
Day
Month
Year
bottom of page